Formulation and Evaluation of Mouth Dissolving Tablet of Ketorolac Tromethamine for Pain Management by Using Superdisintegrants

s: Mouth dissolving tablet is the fast growing and highly accepted drug delivery system. This study was aimed at development of Ketorolac Tromethamine mouth dissolving tablet, which can disintegrate or dissolve rapidly once placed in the oral cavity. Conventional Ketorolac tromethamine tablet require water to swallow it and have disadvantages like low disintegration rate, low solubility etc.Ketorolac Tromethamine mouth dissolving tables ( formulation ) consists of super-disintegrate like Ac-Di-Sol, Polyplasdone XL, and Explotab. Fillermicrocrystalline cellulose (MCC), sweetener aspartame, strawberry flavor and menthol for good mouth feel. Tablets of batch F1 (formulation without disintegrants) was compared with batches F2 to F4 (formulation with disintegrants) and comparison between the three superdisintegrants has shown remarkable results.